Mom, How Do I? It hasn't been updated in a couple of years (meaning someone *cough* me *cough* should probably archive them,) but it features videos on skills that you'd typically learn from a mom, like: basic makeup, cleaning, and cooking/baking.
Dad, How Do I? The brother channel to Mom, How Do I? It features videos on skills you'd typically learn from a dad, like home repairs, mens wear, and cooking.
Dollar Tree Dinners Guides on how to make meals exclusively from Dollar Tree. Useful if you're on a extremely limited budget.
Politics/Pop Culture
Dead Domain Video essays about the trans experience, the current political sphere, and leftism.
Alex Avila Similar to Dead Domain, videos about popular culture and politics.
ContraPoints Another in the style of Dead Domain, she uploads incredibly in depth videos about once a year about her feelings, politics, and pop culture.
Kat Blaque A woman with incredible work in political analysis. She formed a decent part of my understanding of our world and socity's relation to its people.
Lani's Lens Videos about black culture and its relation to pop culture.
Ask a Mortician Mortician who makes videos about famous deaths, death-related myths, and anything else death related.
Captain Disillusion Videos about SFX and how famous internet hoaxes are made.
Coaster College Videos about rollar coaster accidents, and the how and why of what happened.
STEM
Kyle Hill Videos about nuclear physics and history.
Higgsino Physics Physics explained visually. I'm a particularly big fan of the nuclear physics videos they've been doing recently.
Cinema Therapy Analysis of movies through the lense of a licensed therapist (and a filmographer.) It seems like it'd be a little pop-psychology-y, but it is genuinely very in-depth and well-put. It was useful while working on a psych degree to contextualize concepts from class in a more in-depth example.
PrimerBlobs Simulations of evolution, and the specific sub-scenarios related.
Reject Convenience Tech and why you should probably be more distrusting of it.